Innovative Methodology Effects of vitamin E on mitochondrial dysfunction and asthma features in an experimental allergic murine model

Effects of vitamin E on mitochondrial dysfunction and asthma features in an experimental allergic murine model.

We showed recently that IL-4 causes mitochondrial dysfunction in allergic asthma. IL-4 is also known to induce 12/15-lipoxygenase (12/15-LOX), a potent candidate molecule in asthma. Because vitamin E (Vit-E) reduces IL-4 and inhibits 12/15-LOX in vitro, here we tested the hypothesis that Vit-E may be effective in restoring key mitochondrial dysfunctions, thus alleviating asthma features in an e...

Study of Chenopodium Album Allergenic Extract to Induce Allergic Asthma in Murine Model

Background: The incidence of allergic and asthmatic diseases has been continuously increased in both industrial and developing countries. Extracts from various known allergens are used for the diagnostic and therapeutic purposes. Objective: To investigate the effects of an extract prepared from Chenopodium album (Ch.A.) pollen to induce allergic asthma in BALB/C mice. Methods: BALB/C mice were ...

The Relationship Between Maternal Vitamin E and Progress of Children Asthma: A Review Article

 Asthma is a chronic inflammatory respiratory disease. Nutritional conditions effects on allergic diseases such as asthma. The aim of this study is to find relation of maternal vitamin E and progression of children asthma. This is a review article searched in data base include Google, PubMed, SID, Irandoc, Scopus and up-to-date. Key words for search include maternal vitamin e, asthma, children ...

Features in Experimental Murine Model Dysfunction and Reduces Allergic Asthma Esculetin Restores Mitochondrial

Evaluation of the Effects of Nicotine on Mammalian Target of Rapamycin Complex 2 and Signal Transducer and Activator of Transcription 3 Genes Expression in a Mouse Model of Allergic Asthma: An experimental study

Background & Aims: Allergic diseases have increased in the last decade worldwide and researchers have been trying to introduce new strategies and drugs to treat these types of diseases. Nicotine shows anti-inflammatory properties and the studies have revealed that it can reduce the inflammation and the allergic responses. The mammalian target of rapamycin (mTOR) is a multifunctional protein kin...